Spravato® Ketamine Therapy in Houston When Antidepressants Have Not Worked

FDA-approved esketamine nasal spray administered under medical supervision at our Houston clinic. Fast relief for treatment-resistant depression — many patients feel improvement within 24 hours.
FDA-Approved 2019 · Covered by Most Insurance · Supervised In-Clinic Sessions · Nasal Spray, Not IV Infusion

Spravato® vs IV Ketamine — What's the Difference?

✓ Spravato® — What Castle HCS Offers ✗ IV Ketamine — NOT Offered Here
FDA-approved nasal spray IV infusion — not FDA-approved for depression
Administered under medical supervision Administered via IV drip
Covered by most insurance after 2 failed antidepressants Usually not covered by insurance
REMS program — highest safety standards No standardized safety monitoring program

You May Qualify for Spravato® If:

✓  You have been diagnosed with major depressive disorder (MDD)
✓  You have tried at least 2 different antidepressant medications without adequate relief
✓  Your depression significantly impacts your work, relationships, or daily functioning
✓  You are currently taking an oral antidepressant (Spravato® works alongside it)
✓  You are an adult seeking treatment in the Houston metro area

Not sure if you qualify? Call (832) 834-3830 — our team will assess your eligibility before you commit to anything.

Your Spravato® Treatment Journey

Your treatment is carefully phased to maximize both safety and effectiveness.

Phase 1 — Weeks 1–4

Induction

2 nasal spray sessions per week. Each session is ~2 hours including administration and post-dose monitoring. Blood pressure monitored throughout.

Phase 2 — Weeks 5–8

Maintenance

1 session per week. Provider adjusts timing based on clinical response. Many patients report noticeable improvement by end of Phase 1.

Phase 3 — Ongoing

Continued Care

Continued sessions as clinically needed, integrated with your oral antidepressant and any therapy you receive.

Every Session

During Your Visit

You self-administer under provider supervision. Remain in clinic 2 hours post-dose. Must arrange a ride home — no driving same day.

Most Insurance Plans Cover Spravato® After 2 Failed Antidepressants

We Handle Everything For You

If you have tried two or more antidepressant medications without adequate relief, that is the standard threshold most insurance plans use to authorize Spravato® coverage.

Our team handles the prior authorization on your behalf. We submit paperwork, follow up with your insurer, and verify your benefits before your first session. You do not deal with the insurance company — we do.

UnitedHealthcare
Anthem Blue Cross
Cigna
Aetna
Optum

✓ Your insurance may cover this. Find out in under 5 minutes.

We handle verification, prior authorization, and all insurance paperwork for you.

What Our Patients Say

Real experiences from patients who found relief after years of failed treatments.

“I had tried four different antidepressants over three years. Nothing stuck. After my third Spravato® session, I woke up and something was genuinely different. I felt like myself again.”

— Michael D.

Condition: Treatment-Resistant Depression

“I was nervous walking in. But the team was so calm and professional. I felt safe the entire time. By week two, my husband noticed the difference before I did.”

— Rachel A.

Condition: Treatment-Resistant Depression

Common questions

Is Spravato® the same as ketamine infusion therapy?

No. Spravato® (esketamine) is an FDA-approved nasal spray, not an IV infusion. It is administered at our Houston clinic under medical supervision as part of the REMS program. IV ketamine is a different treatment and is not offered at Castle HCS.

Many patients report meaningful improvement within 24 hours of their first session. Full effect builds over the 4-week induction phase. Individual results vary.

You may experience temporary dissociative effects — a dreamlike or detached feeling. These are expected, monitored by our providers, and typically resolve within the 2-hour post-dose period. You are never alone.

 Yes. Secure video appointments for patients throughout Texas. In-person care at 6666 Harwin Drive, Suite 155, Houston TX 77036.

Yes. Our board-certified providers manage antidepressants, anti-anxiety meds, ADHD medications, mood stabilizers, and sleep medications.

Relief From Depression May Be Closer Than You Think.

Spravato® REMS consultations in Houston. Insurance verified before your first session.